Likewise, Serebriskii et al., in their study, observed that the overall frequency of KRAS alterations increased in Microsatellite stable (MSS)/tumor mutation burden low (MT-L) patients with age, whereas microsatellite instability-high/tumor burden high (MT-H) patients had reduced alterations of KRAS with age [143]. The gene discussed is KRAS; the disease is neoplasm.