The identification of mediating factors of OIS in pediatric low-grade gliomas was the subject of a previous work by Buhl et al., who analyzed gene and protein expression during a state of proliferation and senescence in a previously mentioned patient-derived KIAA1549::BRAF fusion positive pilocytic astrocytoma (PA) model, which allows for doxycycline-inducible switching between a proliferative state and OIS [122,124]. Here, BRAF is linked to pilocytic astrocytoma.