CDKN2A and pilocytic astrocytoma: Similar to preclinical models of pilocytic astrocytoma, enhanced expression of hallmarks of senescence including p16INK4a and acidic β-galactosidase, as well as a significantly upregulated mRNA expression of senescence-associated secretory phenotype (SASP) factors, was shown in human pilocytic astrocytoma samples, possibly indicating the significance and translational potential of the observations in preclinical in vitro models to clinical routine [120,122].