CDKN2A and pilocytic astrocytoma: In a patient-derived KIAA1549::BRAF fusion positive pilocytic astrocytoma model, a doxycycline-inducible switching between a proliferative state and OIS by doxycycline-inducible inhibition of TP53/CDKN1A and CDKN2A/RB1 pathways was implemented, while the induction of CDKN1A and an accumulation of TP53 with subsequent G1 growth arrest was shown during a senescent state [122,124].