In a genetically engineered neurofibromatosis 1 mouse model, multi-potent low-grade glioma stem cells failed to generate glioma-like lesions in athymic mice lacking T cells or chemotactic receptors such as CCR2 and chemokine c-motif ligand 5 (CCL5), which mediate the interaction of T cells and microglia and moreover were shown to promote low-grade glioma growth [175,176]. This evidence concerns the gene CCR2 and central nervous system cancer.