The subtypes of MBs are currently characterized by molecular and clinical features [102] and are designated as: group 1 WNT-MB and group 2 Sonic Hedgehog (SHH)-MB, which are characterized by the constitutive active signaling of WNT and SHH, respectively; and group 3 and group 4, which are characterized by a preponderance of somatic copy number aberrations (SCNAs) and structural variants (SVs) [103]. This evidence concerns the gene SHH and Mobius syndrome.