In high-grade MPNST, an aggressive sarcoma with poor prognosis and no effective targeted therapy, the targeting of DNMT1 with decitabine or DNMT1-selective catalytic inhibitor GSK3685032 caused the transcriptional activation of ERV retrotransposons and subsequent viral mimicry-mediated cell death [242]. The gene discussed is DNMT1; the disease is sarcoma.