↑, Induction; ↓, reduction; n.a., not applicable; MB, medulloblastoma; NB, neuroblastoma; ETMRs, embryonal tumor with multilayered rosettes; OS, osteosarcoma; EwS, Ewing sarcoma; RMS, rhabdomyosarcoma; GBM, glioblastoma; GIST, gastrointestinal stromal tumor; MPNST, malignant peripheral nerve sheath tumor; TMZ, Temozolomide; PARPi, PARP inhibitor. The gene discussed is PARP1; the disease is medulloblastoma.