We have characterized the ability of pluripotent stem cells derived from undiagnosed control individuals (C) and from patients with BP who carry a single nucleotide polymorphism (SNP), rs1006737, in the L-type calcium channel gene CACNA1C, which regulates calcium influx and has been associated with SZ [18,19], schizophrenia [20,21] and major depression [22], to mature and function. The gene discussed is CACNA1C; the disease is major depressive disorder.