We also investigate the consequences of WDR5B depletion in stem cell-derived retinal pigment epithelial cells (hESC-RPE), a differentiated cell type of neuroectodermal origin with high relevance for the treatment of retinal diseases such as age-related macular degeneration (AMD) and proliferative vitreoretinopathy (PVR) [39,40,41]. The gene discussed is WDR5B; the disease is age-related macular degeneration.