Significant reciprocal dynamics were present in mononuclear cells and CD206+ monocytes during therapy in the blood of patients with PE on dienogest presenting with treatment-related amenorrhea: a decrease in CD206+ monocytes and a parallel increase in mononuclear cell counts (Wilks’ lambda = 0.441, F = 10.76, p = 0.0009). Here, MRC1 is linked to amenorrhea.