Moreover, to improve the efficacy and drug availability of crocin, Awad et al. combined it with saffron, a multi-kinase inhibitor, which showed higher anticancer effects in the cirrhotic rat model of HCC by downregulating the NF-κB-p65, COX-2, and β-catenin [37]. This evidence concerns the gene NFKB1 and hepatocellular carcinoma.