Chen et al. (2022) illustrated that curcumin administered at doses spanning from 10 to 40 μg/mL in HCC and HCCLM3 and Huh7 cell lines, and 200 mg/kg/day in an animal model, showed to effectively target Vimentin, circ_0078710, MMP-9, and Bax, leading to induce apoptosis and inhibit cell growth and migration [130]. This evidence concerns the gene MMP9 and hepatocellular carcinoma.