ACHE and Alzheimer disease: In addition to the deposition of Aβ fibrils, NFTs, inflammatory reactions, and oxidative stress responses, the features of AD also include the loss of cholinergic neurons, the neurotransmitter acetylcholine (ACh), and its synthesizing enzymes, choline acetyltransferase, and acetylcholinesterase (AChE)-degrading enzyme [56,57,58,59,60].