However, EBV-miR-Bart1-5P activates the AMPK/mTOR/HIF-1 pathway by targeting the α1 catalytic subunit of AMPK (AMPKα1) in NPC cells [86], suggesting that a feedback mechanism may exist between EBV infection and AMPK. The gene discussed is PRKAA1; the disease is nasopharyngeal carcinoma.