NFE2L2 and nasopharyngeal carcinoma: EBV-EBNA1 upregulates SLC7A11 and GPX4 expression and activates NRF2 by degrading Kelch-like ECH-associated protein 1 (Keap1) in a p62-dependent way, which thereby reduces the sensitivity of NPC cells to ferroptosis [17] (Figure 2).