Thus, treatment with liposomes for 14 days in obese animals did not promote changes in enzymatic antioxidants (SOD, CAT, GST, and GPx), but the TBARS marker, a sign of lipid damage, remained elevated (groups P and O) in liver tissue, without causing protection against obesity, and both triggered lipoperoxidation during this treatment period. Here, SOD1 is linked to obesity due to melanocortin 4 receptor deficiency.