Obesity increases pro-inflammatory adipokines, such as interleukin-6 (IL-6), Alpha Tumor Necrosis Factor (TNF-α), adiposin, angiotensinogen, leptin, resistin, and visfatin, while decreasing the expression of anti-inflammatory adipokines, such as interleukin-10 (IL-10) and adiponectin, both in the systemic circulation and in tissues [8]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.