Various drugs and biologics, such as proteasome inhibitors, Bcl-2 inhibitors, IAP antagonists, histone and deacetylase inhibitors, as well as natural compounds like resveratrol, quercetin, and Strophanthidin (SPTD), have been used in combination to sensitize tumor cells to TRAIL [95,96,97]. The gene discussed is TNFSF10; the disease is neoplasm.