Endothelial dysfunction, in addition to the action of AGEs, is induced by the positive regulation of biomolecules such as vascular endothelial growth factor and plasminogen activator inhibitor-1 (PAI-1), leading to neoangiogenesis and increasing the pro-thrombotic state essential for the development of CVD [17,18]. This evidence concerns the gene SERPINE1 and endothelial dysfunction.