In accordance with these results, Zhou et al. fed black onion polysaccharide extracts to T2DM mice suffering from alloxan-induced liver and kidney damage and found that the polysaccharides effectively increased the SOD activity, reduced the reactive oxygen species and dialdehyde contents, and alleviated oxidative stress, thus protecting the liver and kidney cells of the mice [48]. Here, SOD1 is linked to type 2 diabetes mellitus.