BRCA2 and DNA repair disease: In the group of patients with poorer survival (less than 3 years), PD-1 signaling may be one of the most affected related pathways, along with the signaling of defective homologous recombination repair (BRCA2 loss of function) and signaling associated with diseases of DNA repair, diseases associated with TLR signaling cascade, immune system diseases, and mitochondrial translation (Figure 8B).