TGFB1 and autoimmune disease: Further, the up-regulation of transforming growth factor-β (TGF-β) is induced by an increase in inflammatory mediators to suppress the inflammatory response [49], and chemokine 10 (CXCL10) is also associated with inflammatory diseases, autoimmune diseases, an tumors, and has antibacterial immunity when activated [50], but in this experiment, tgf-β and cxcl10 were both decreased significantly by copper stress.