One of the studies reported that dapagliflozin recovered cholesterol metabolism functions in type 2 diabetes mellitus (T2DM) mice liver via activating the antioxidant Nrf2/HO-1 pathway, highlighting the involvement of this pathway in dapagliflozin-mediated hepatoprotection protection [49]. The gene discussed is HMOX1; the disease is type 2 diabetes mellitus.