An in vivo study using spheroids from 4T1 and MMT (murine mammary tumor cells, E-cad-negative) implanted into the murine mammary fat demonstrated that cells left the spheroid and migrated collectively, and some of them presented spindle-like or elongated morphology; cells were able to detach and migrate individually (suggesting an EMT process), forming micro- and macrometastases in the lung [17]. Here, CDH1 is linked to breast cancer.