COL5A3 and eosinophilic esophagitis: Pathway enrichment analysis in F_B sub-cluster showed upregulation of epithelial–mesenchymal transition with upregulation of top leading genes TNC, POSTN, MXRA5, LOXL2, SAT1, COL5A3, WNT5A, COL12A1, COL6A3, and CD44 in active versus remission EoE (Figure 4d).