Pathway enrichment analysis in F_B sub-cluster showed upregulation of epithelial–mesenchymal transition with upregulation of top leading genes TNC, POSTN, MXRA5, LOXL2, SAT1, COL5A3, WNT5A, COL12A1, COL6A3, and CD44 in active versus remission EoE (Figure 4d). Here, TNC is linked to eosinophilic esophagitis.