TARDBP and amyotrophic lateral sclerosis: Ourneuronal nuclei proteomics identified chromatin regulators implicatedin neurodevelopmental conditions, such as TBR1 syndrome (or intellectualdevelopment disorder with autism and speech (IDDAS) delay) and amyotrophiclateral sclerosis (ALS)/frontotemporal lobar degeneration (FTLD) (TDP-43,protein product of Tardbp)45,46 (Table 1).