Na+ influx is known to serve as the driving force for Cl− loading, leading to cytotoxic neuronal swelling in ischemic stroke.[9] To test if the SWELL1 channel can be activated by intracellular hypertonicity with increased NaCl concentration, we first performed patch‐clamp recordings in HeLa cells with the normal internal solution plus additional NaCl. This evidence concerns the gene LRRC8A and ischemic stroke.