Consistent with previous reports,[23, 27] the mRNA and protein levels of SWELL1 increased significantly after tMCAO in the TTC+ peri‐infarct region compared to the contralateral hemisphere and the TTC− infarct core (Figure 1B–D), indicating that SWELL1 expression is upregulated in response to ischemia. The gene discussed is LRRC8A; the disease is ischemia.