Our results show that, during the primary transplant phase, BCR-ABL1+ B-ALL mice expressing Rag1c/c or Rag2 c/c demonstrated lower survival rates compared to their counterparts with Ragf/f (median 74.5 days vs 39 or 57 days, p < 0.0425, Figure 1A). This evidence concerns the gene RAG2 and precursor B-cell acute lymphoblastic leukemia.