ACE2 and Alzheimer disease: In stage 2, we performed a cross‐trait association analysis, and found 19 genetic variants that were significantly associated with both AD and circulating ACE2 at the genome‐wide significance p < 5.00E‐08 at chromosome 6p21.32, 8p21.2‐p21.1, 17p13.2, and 19q13.32.