ISG encoding chemo-attractants like CXC-motif chemokine 10 (CXCL10) lead to an increase in tumor-infiltrating leukocytes (TIL; ref. 12) and by stimulating DC maturation and enhancing their capacity to process and present tumor cell–associated antigens, ISG promote TIL priming and activation (13). This evidence concerns the gene CXCL10 and neoplasm.