A comprehensive cancer genomic profile (CGP) test (FoundationOne® CDx; Foundation Medicine, Inc., Cambridge, MA, USA) on the resected parathyroid tumor revealed a novel MEN1 mutation (NM_130801: exon2: c.332delG: p.G111fs*8), and the lack of this mutation in peripheral blood sequencing with multiplex ligation–dependent probe amplification suggested its somatic nature. Here, MEN1 is linked to tumor of parathyroid gland.