PDYN and epilepsy: Noticeably, alterations of genes’ expression regulating GABA receptor subunits, as well as potassium channels, have been linked with the disruption of inhibitory network development and/or activity modulation, being considered as one of pathophysiological mechanisms underlying multiple types of epilepsy.96-98 Additionally, we also observed a relationship between the aperiodic exponent and the cortical expression of the PDYN in the TLE patients group.