NFE2L2 and X-linked adrenoleukodystrophy: A study revealed that master regulator of the endogenous antioxidant response nuclear factor 2 erythroid 2-like 2 (NRF2) in both ABCD1-KO mice and X-ALD human fibroblasts has impaired activity due to impaired AKT/GSK-3β-NRF2 axis.