,2,3 Currently, there are three main therapies for cardiovascular disease (CVD): statins (inhibitors of β-hydroxy β-methylglutaryl-CoA [HMG-CoA] reductase [HMGCR]),4,5 ezetimibe (inhibitors of Niemann-Pick C1-like 1 [NPC1L1]),6,7 and certain types of proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors.8 The gene discussed is PCSK9; the disease is cardiovascular disorder.