KCNQ1 and type 2 diabetes mellitus: Although the affected KCNQ1 locus is located in an imprinted genomic region, and KCNQ1 is considered a risk gene for type 2 diabetes,12,13,19 our data show that the C1189T mutation does not alter the epigenetic regulation of gene expression in the imprinted KCNQ1 locus during pancreatic differentiation.