,22 Although NMUR1 is widely expressed on many immune cells, such as macrophages, endothelial cells, ILC2, and CD8+ T cells, especially in the gastrointestinal tract, and is known to interact with NMU in the tumor microenvironment and drug resistance, its role in the CRC microenvironment and treatment remains unclear. The gene discussed is CD8A; the disease is colorectal carcinoma.