IHC analysis, in mice receiving daily HIF-1α siRNA injections has confirmed the macroscopic image of reduction of tumor volume through the decreased levels of HIF-1α transcriptional targets, like VEGF, GLUT–1, c-MET, and CA-IX and markers for cell growth like MIB-1 and MVD [115] (Table 6). This evidence concerns the gene CA9 and neoplasm.