Nimbolide, another neem limonoid was demonstrated to inhibit angiogenesis in breast cancer cells as well as in a xenografted nude mouse model of breast cancer by AR inhibition with the consequent abrogation of the insulin-like growth factor-1 (IGF-1)/PI3K/Akt and HIF-1α/VEGF signaling. The gene discussed is AKT1; the disease is breast carcinoma.