AKR1B1 and hepatocellular carcinoma: In HCC cells, Man et al. [144] demonstrated that downregulation of the epidermal growth factor receptor substrate 15 (EPS15) by the lncRNA EPS15-antisense1 (EPS15-AS1) reduced AKR1B1 expression with consequent stimulation of ferroptosis, inhibition of invasion, and disruption of the redox balance.