EGF and colorectal carcinoma: In EGF-stimulated CRC cells, fidarestat potentiated EGF-induced Nrf2 and upregulated the expression of peroxisome proliferator-activated receptor gamma coactivator (PGC)-1alpha, transcription factor A, mitochondrial (TFAM), and COX-IV and attenuated DNA damage as seen by decreased levels of 8-hydroxy-2'-deoxyguanosine.