PDCD4 and colonic neoplasm: Inhibition of AR was found to prevent the growth of HT29, SW480, and Caco-2 colon cancer cells and nude mice xenografts by downregulating miR-21 expression with concomitant upregulation of programmed cell death 4 (PDCD4), a target of miR-21 by modulation of the ROS/AMPK/mTOR/AP1/4E-BP1 pathway [142].