At the same time, the ESR is known to be a non-specific indicator of inflammation and is described to be used in inflammation estimation in different recent RA research (26), Normal control group indicated the significantly smallest level of both CRP and RF (4.17±0.75 and 9.03±1.17, respectively) compared to all other FCA-induced groups, which signifies the inflammation induction to the animals. Here, CRP is linked to rheumatoid arthritis.