Such differences lead to more severe forms and sustained inflammatory progression in the ACPA-positive subtype.Additionally, this study further substantiates through multifactorial logistic regression analysis that the infiltration levels of CD3+ T lymphocytes and CD20+ B lymphocytes significantly correlate with ACPA titers (OR = 5.88, 3.63; P = 0.009, 0.049).T and B lymphocytes are significant in the context of ACPA-positive RA [3].T cells, being the most prevalent immune cells in RA synovitis, play a dual role. The gene discussed is PRTN3; the disease is rheumatoid arthritis.