Given the cold immune subtype of prostate tumor, Kaplan Meier analysis in our study revealed shortened PFS correlation with high baseline sPD-L1 values in PCa, as in many other tumors characterized by non-immunologically cold TME such as HCC (45), gastric cancer (46, 47), breast cancer (BC) (48) glioma (41) and several NSCLC studies (14, 49, 50). The gene discussed is SPDL1; the disease is non-small cell lung carcinoma.