Based on the possible systemic effect of soluble PD-L1 and PD-1, our analysis revealed a positive correlation between sPD-L1 and immunosuppressive circulating CD4+CD25+FOXP3+ T regulatory cells in PCa patients with an unfavorable course of disease, suggesting potential role of this interaction in disease progression and upregulated immunosuppressive activity. This evidence concerns the gene FOXP3 and posterior cortical atrophy.