Elevated concentrations of circulating sPD-L1 were found in many cancers compared to controls, - in two separate studies of gastric cancer (GC) (34, 35) in hepatocellular carcinoma (HCC) (36) lung adenocarcinoma (37) clear cell renal cell carcinoma (ccRCC) (12), in different types of carcinomas (38), ovarian cancer (OC) (39), glioma (40, 41). This evidence concerns the gene SPDL1 and clear cell renal carcinoma.