We made unexpected findings that the percentage of CD8 and CD4 TILs was much lower in eradicated (C-225) tumor than growing one (C-100); nevertheless, the TILs in C-225 exhibited a lower level of PD-1 and LAG-3 expression and demonstrated more robust effector functions than their counterparts in C-100. This evidence concerns the gene LAG3 and neoplasm.