The findings of the IVW method revealed that IL-10 receptor subunit beta (IL-10RB) (OR = 1.097, 95% CI = 1.009–1.192, p = 0.029), IL-18 receptor 1 (IL-18R1) (OR = 1.083, 95% CI = 1.018–1.153, p = 0.012) and TNF-related activation-induced cytokine (TRANCE) (OR = 1.119, 95% CI = 1.002–1.249, p = 0.045) were correlated with an elevated risk of AD. The gene discussed is TNFSF11; the disease is Alzheimer disease.