In addition, the IVW method also revealed causal relationships between circulating levels of CXCL11 (OR = 0.878, 95% CI = 0.783–0.984, p = 0.025), IL-33 (OR = 0.809, 95% CI = 0.661–0.991, p = 0.041), TNF-beta (TNF-β) (OR = 0.945, 95% CI = 0.896–0.997, p = 0.038) and CD5 (OR = 0.764, 95% CI = 0.652–0.895, p = 8.26e-04) and a decreased risk of AD. The gene discussed is CD5; the disease is Alzheimer disease.