Figures 4A, C display the medians and IQR of CD4+ T-cell count and CD4+/CD8+ ratio trajectories throughout the follow-up for the 3DR and 2DR (p= 0.941 and p= 0.565, respectively), without differences between the 3DR and 2DR adjusted for possible confounders, including age, sex, risk for HIV infection, highest viral load before starting ART, and number of blips throughout the follow-up (F= 0.351, p= 0.555 and F= 1.601, p= 0.327, respectively) (Figures 4B, D). The gene discussed is CD8A; the disease is HIV infectious disease.