In the prognostic model, the risk score calculation formula for each HCC sample is Risk score = (−0.000337128 × C3) + (0.009464722 × CTNNB1) + (0.045920338 × CYBC1) + (−0.035384453 × DNASE1L3) + (0.007516301 × IRAK1) + (0.001958146 × SERPINE1). This evidence concerns the gene IRAK1 and hepatocellular carcinoma.