The GEPIA database was further analyzed for six Hub genes, mRNA expression of CYBC1 (HR = 1.7, Logrank p = 0.0036), DNASE1L3 (HR = 0.43, Logrank p = 2e-06), IRAK1 (HR = 1.7, Logrank p = 0.0042), SERPINE1 (HR =1.5, Logrank p = 0.027) mRNA expression correlated with overall survival of hepatocellular carcinoma patients as shown in Supplementary Figure S3. This evidence concerns the gene SERPINE1 and hepatocellular carcinoma.