Indeed, among older Veterans with albuminuria and diabetes, both urinary biomarkers have been associated with eGFR decline and mortality (124); furthermore, in a sub-cohort of CKD patients from the SPRINT study, YKL-40 and MCP-1 levels predicted CKD progression and the onset of CKD over 3.8 years of median follow-up time (122). This evidence concerns the gene CHI3L1 and chronic kidney disease.