IVW analysis indicated that AMFR [OR = 0.977; 95% CI, 0.956–0.998; P = 0.030], LAP3 [OR = 0.967; 95% CI, 0.934 0.997; P = 0.048], RABAC1 [OR = 0.928; 95% CI, 0.875 0.985; P = 0.015], and TPSB2 [IVW: OR = 0.971; 95% CI, 0.943 0.999; P = 0.049] were inversely correlated with AF risk. This evidence concerns the gene LAP3 and atrial fibrillation.