Some DEGs linked to depression and neuroinflammation (BDNF (Porter and O'Connor, 2022), CCL2 (Curzytek and Leśkiewicz, 2021), STC1 (Chao et al., 2021), MEF2C (Hyde et al., 2016)) were also downregulated in Cit200 over time (Figure 2G). This evidence concerns the gene CCL2 and depressive symptom measurement.