Interestingly, some of the linear dose-response DEGs have been implicated in transmission and plasticity (GRIN2A (Paoletti et al., 2013), GAD2 (Pan, 2012)), depression and antidepressant effect (DDIT4 (Wang et al., 2018), GAD2 (Unschuld et al., 2009)) anxiety and stress responses (ADCYAP1R1 (Oyola and Handa, 2017; Wang et al., 2021)), WNT signalling (FRZB (Mitsiadis et al., 2017)), neurogenesis (ARHGEF39 (Anijs et al., 2022)) and hippocampal volume (ANKRD37 (Xu et al., 2022)) (Figure 4C). This evidence concerns the gene ARHGEF39 and major depressive disorder.