Some DEGs linked to depression and neuroinflammation (BDNF (Porter and O'Connor, 2022), CCL2 (Curzytek and Leśkiewicz, 2021), STC1 (Chao et al., 2021), MEF2C (Hyde et al., 2016)) were also downregulated in Cit200 over time (Figure 2G). Here, CCL2 is linked to depressive disorder.