LIMK1 and posterior cortical atrophy: LIMK1/2-mediated phosphorylation of cofilin emerges as a critical therapeutic target in PCa management, inhibiting cofilin severing activity, cytoskeletal reorganization, filopodia formation, and chromosomal abnormalities to impede PCa progression at early stages (Davila et al., 2003; 2007; Shah and Cook, 2023).