Conversely, alpha-2-macroglobulin (α2-MG), nuclear clusterin (nCLU), and anchoring protein AKAP2 exert reverse control over cofilin dephosphorylation and activation, thereby influencing the dynamics of actin filaments to promote PCa cell invasion and metastasis (Misra et al., 2005; Moretti et al., 2011; Reggi et al., 2024). This evidence concerns the gene CFL1 and posterior cortical atrophy.