CFL1 and neoplasm: Rho family GTPases, including RhoA, RhoB, Rac1, and Rac2, elicit tumor-suppressive effects by activating PAK4, ROCK, or directly stimulating the LIMK/cofilin signaling pathway (Ahmed et al., 2008; Alfano et al., 2012; Lee et al., 2019; X; Zhang et al., 2019).