We hypothesize that presence of an A allele at −511 (IL-1β promoter; rs16944) or a C allele at −174 (IL-6 promoter; rs1800795) is associated with domain-specific cognitive decline whereas an A allele at −308 in the TNFα promoter (rs1800629) is protective against decline in global function, episodic memory, attention/working memory, and executive function in the same non-demented older adults. This evidence concerns the gene IL1B and Mental deterioration.