Changes in the levels of T lymphocytes (CD3+, CD4+, and CD8+), B lymphocytes (CD3−CD19+), immunoglobulins (IgG, IgM, and IgA), and cytokines (IL-1β, IL-2R, and IL-6) often indicate immune deficiencies in the body. The gene discussed is CD40LG; the disease is Immunodeficiency.