IFN is divided into type I (IFNα and IFNβ) and type II (IFNγ), of which type II is mainly secreted by immune cells: T-helper (Th) 1 cells, natural killer cells (NK cells), etc. Expression of IFN in OVs can effectively induce tumor cell death through modulation of various pathways (22). This evidence concerns the gene IFNG and neoplasm.