EGFR and central nervous system cancer: On the other hand, multiple miRNAs have been identified to target oncogenes and play tumor suppressive roles as is the case for miR-7 (downregulated in GBM) by targeting PI3K and Raf-1 via the EGFR pathway, (Liu et al., 2014) and miR-128 was found to decrease glioma cell proliferation by targeting E2F3a (Zhang et al., 2009).