VEGFA and retinopathy of prematurity: Sen et al reported that the percentages of a plus disease were 52% and 25.5% for stages 4A and 4B ROP, respectively.[17] Similarly, Karacorlu et al reported that the percentages of plus disease were 89%, 82%, and 16% in stages 4A, 4B, and 5 ROP, respectively.[18] Preoperative treatments included laser photocoagulation, intravitreal anti-vascular endothelial growth factor (VEGF) injection, or both.