GSK3B and Alzheimer disease: Although the exact mechanism by which lithium acts in AD treatment remains unclear, its inhibition of glycogen synthase kinase-3beta (GSK-3β) and modulation of inositol monophosphatase (IMPase) are thought to be crucial and are the focus of this review (Chalecka-Franaszek and Chuang, 1999; Sarkar and Rubinsztein, 2006).