A number of studies have shown that insulin resistance is effectively inhibited after treatment with a certain dose of silymarin administered to an animal model of insulin resistance, which is achieved by restoring the IRS-1/P13K/Akt pathway and blocking the phosphorylation of c-Jun N-terminal kinase (JNK) and inhibitor of kappa B kinase (Zhang et al., 2013a; Li et al., 2015; Guo et al., 2016). Here, IRS1 is linked to Insulin resistance.