CD44 and hepatocellular carcinoma: However, the main findings are based solely on one CD44 high HCC cell line (Huh7), and a second CD44-high HCC cell line or a CD44 knockout line of Huh7 cells and a CD44-overexpressing line of HepG2 maybe needed to be used to provide more robust evidence for the efficacy of HA-Lip-ICT.